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Search for "oligonucleotide binding" in Full Text gives 3 result(s) in Beilstein Journal of Organic Chemistry.
Pyrene–nucleobase conjugates: synthesis, oligonucleotide binding and confocal bioimaging studies
Beilstein J. Org. Chem. 2017, 13, 2521–2534, doi:10.3762/bjoc.13.249
- . Confocal microscopy confirmed that 5 predominantly stains mitochondria but it also accumulates in the nucleoli of the cells. Keywords: confocal microscopy; luminescence; nucleobases; oligonucleotide binding; pyrene; X-ray; Introduction Pyrene is a planar, polycyclic aromatic hydrocarbon which shows well
- synthesis, DFT calculations, photophysical characterization, oligonucleotide binding studies, and confocal microscopy studies of the novel pyrene–nucleobase conjugates 2–5 (nucleobase = thymine (2 and 4), and adenine (3 and 5)). Our compounds represent a simple bifunctional design combining the fluorescent
Terminal lipophilization of a unique DNA dodecamer by various nucleolipid headgroups: Their incorporation into artificial lipid bilayers and hydrodynamic properties
Beilstein J. Org. Chem. 2015, 11, 913–929, doi:10.3762/bjoc.11.103
- lipophilicity of the nucleolipid head group is of minor importance for the effectiveness of lipo-oligonucleotide binding within the artificial lipid bilayer with respect to (i) the maximal bilayer brightness, (ii) the binding rate to reach this maximum brightness, (iii) the stability of the LON within the
Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)
Beilstein J. Org. Chem. 2013, 9, 717–732, doi:10.3762/bjoc.9.82
- binding of TDP-43 to nucleotides. Cassel et al. [42] developed a high-throughput screening assay whereby TDP-43 nucleotide binding could be assessed. A screen of 7360 compounds yielded a series of small molecules that disrupt oligonucleotide binding to TDP-43 protein [42]. Later, this series of 4
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